Cholesterol Metabolism

The pathological basis of cardiovascular and cerebrovascular diseases is atherosclerosis (ASCVD). While dyslipidemia is an important risk factor for ASCVD, studies have found a clear causal relationship between hypercholesterolemia and atherosclerotic disease. To control ASCVD, blood lipids must be controlled. Clinical studies have found that blood lipids are very complex, mainly including total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), lipoprotein (a), ApoA1, ApoB and so on. Clinically, too high plasma total cholesterol (TC) and/or triglyceride (TG) or high density lipoprotein cholesterol (HDL-C) is called lipid abnormality. Abnormal dyslipidemia usually means abnormalities in lipid or sterol metabolism in the body. In addition to dyslipidemia caused by poor lifestyle, it is more due to mutations in lipid or sterol metabolism-related genes. Studies have shown that single-gene mutations cause cardiovascular disease more frequent.